Typical dose100–200 mcg per injection (research standard); 1 μg/kg (~100 mcg) IV bolus in clinical studies
Frequency2–3x per week (standard); every other day or daily in some protocols. Chronic daily use may cause tachyphylaxis (reduced receptor responsiveness).
RouteSubcutaneous (research standard); IV bolus in clinical studies
Cycle4–12 weeks on, followed by a break of equal length before starting again
TimingMorning administration within 90 min of waking to mimic natural pulsatile hormone signaling, or pre-sleep to align with overnight recovery. Injection absorption is food-independent — can be taken with or without food.
NotesChan/Seminara dose-response (KP-10 0.01–1 μg/kg IV) shows peak LH at ~1 μg/kg; KP-54 IVF triggers use 1.6–12.8 nmol/kg SC. 2–3x/week dosing helps prevent receptor fatigue.